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Some people might need to take it 4 times a day. manfaat asam mefenamat 500 mg If you take ibuprofen 3 times a day, leave at least 6 hours between doses If you take it 4 times a day, leave at least 4 hours between doses If you have pain all the time, your doctor may recommend slow-release ibuprofen tablets or capsules You'll usually take these once a day in the evening